Repression of Malignant Tumor Progression upon Pharmacologic IGF1R Blockade in a Mouse Model of Insulinoma
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چکیده
منابع مشابه
Repression of malignant tumor progression upon pharmacologic IGF1R blockade in a mouse model of insulinoma.
NVP-AEW541, a specific ATP-competitive inhibitor of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase, has been reported to interfere with tumor growth in various tumor transplantation models. We have assessed the efficacy of NVP-AEW541 in repressing tumor growth and tumor progression in the Rip1Tag2 transgenic mouse model of pancreatic β-cell carcinogenesis. In addition, we hav...
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ژورنال
عنوان ژورنال: Molecular Cancer Research
سال: 2012
ISSN: 1541-7786,1557-3125
DOI: 10.1158/1541-7786.mcr-11-0522